Examining the uses and side effects of Normskin or isotretinoin tablets

Normskin or isotretinoin is an oral medication used to treat mild to moderate acne. This drug works by reducing the production of fat by the sebaceous glands of the skin and is also known as isotretinoin and rakutan. Acne is a common skin disease and can occur at any age. This disease can cause pimples, blackheads, whiteheads and other skin problems. This product, in addition to various uses, has many precautions and side effects. In the rest of the article, we will examine how it works, safety tips for taking pills, uses, side effects, etc. of isotretinoin pills.

Pharmaceutical forms of Norm Skin

Chemical and herbal medicines available in the market are produced in various pharmaceutical forms based on international standards and classes. These forms include tablets, capsules, serum, ointment, injectable solution, syrup, etc., which the doctor prescribes according to the medical records, physical condition and age of the patient. Normskin medicine in the form of capsules 10 mg, 20 mg, 25 mg, 30 mg, 35 mg, 40 mg and other types of micronized capsules 10 mg, 16 mg, 20 mg, 24 mg , 28 mg and 32 mg are produced.

Uses of Normskin tablets

This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatments (such as benzoyl peroxide or clindamycin applied to the skin or oral tetracycline or minocycline). This drug belongs to a group of drugs called retinoids, which works by reducing the production of facial fat (sebum). It should be noted, high amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring in patients. The most important uses of Normskin tablets (isotretinoin) are severe and unruly nodular acne, which can be used with the approval and prescription of a doctor.

Pharmacological effects and mechanism of action of isotretinoin drug

retinoid; It inhibits the function of sebaceous glands and keratinization. For this reason, the clinical improvement of nodular acne is related to the reduction of sebum secretion. Norm Skin has 99.9% protein binding (primarily albumin). This product is metabolized by liver oxidation through CYP2B6, CYP2C8/9 and CYP3A4 liver isozymes. Also, 65 to 83% of the drug is excreted in relatively equal amounts through feces and urine.

Dosage of isotretinoin tablets

Before taking Normskin tablets, read the drug information on the product packaging. Take this medicine orally as directed by your doctor. The recommended dose for general use is usually twice a day for 15 to 20 weeks. Do not keep the capsule in your mouth and swallow completely after eating. Some producers of this product emphasize that it should be taken with food so that your stomach and digestive system are not disturbed. Food also helps increase the absorption of this drug into your bloodstream.

Dosage of Normskin tablets in severe nodular acne

1. For the treatment of severe nodular acne in non-pregnant patients with micronized capsules: 0.8-4 mg daily for 15-20 weeks.
2. For the treatment of severe nodular acne in non-pregnant patients with capsules: 1-5 mg daily for 15-20 weeks.
3. Adults whose disease is very severe with scarring or occurs primarily on the trunk require a dose of up to 2 mg/kg/day (if tolerated).

Time to take Normskin medicine

Take this medicine with a full glass of water (8 oz/240 ml) unless your doctor tells you otherwise. Dosage is based on medical condition, weight and response to treatment. Do not lie down for at least 10 minutes after taking this medicine. The manufacturers of Normskin tablets do not approve long-term use without a doctor’s prescription. This pill can be absorbed through the skin and lungs and harm the baby inside the belly of pregnant women. Pregnant women should consult their doctor and pharmacist regarding the time of use.

Precautions

This product contains inactive ingredients (such as soy, parabens) that can cause allergic reactions or other problems. Some people who are allergic to peanuts may also be allergic to soy, talk to your pharmacist for details. If you have medical history such as diabetes, family or personal history of high blood fat (triglyceride), mental or creative problems (such as depression), liver disease, obesity, eating disorders (such as anorexia nervosa), alcohol abuse, pancreatitis, conditions of loss Bone (such as osteoporosis or osteomalacia, decrease in bone density) and… use Rakutan (isotretinoin) with caution and as directed by your doctor.

1. Neutropenia and agranulocytosis (rare) have been reported in patients. Discontinue use if white blood cell count drops significantly.
2. Avoid donating blood during the treatment and up to one month after stopping the treatment due to the risk of fetal toxicity.
3. A pseudotumor of the brain has been reported, some reports involving the concomitant use of tetracycline. For this reason, simultaneous treatment with tetracyclines should be avoided. (Primary signs and symptoms of intracranial blood pressure include papillary edema, headache, nausea, vomiting, and visual disturbances)
4. Serious skin reactions have been observed in some patients. Discontinue treatment if skin reaction occurs.
5. Increased levels of triglycerides and total cholesterol have been seen in patients.
6. Patients who experience tinnitus or hearing impairment should discontinue treatment and be referred to specialist care for further evaluation.
7. Musculoskeletal symptoms including arthralgia and rhabdomyolysis may occur in patients. Discontinue treatment if any significant abnormalities are observed.
8. Avoid prolonged exposure to UV rays or sunlight.
9. Hypersensitivity reactions (eg, anaphylactic, cutaneous, allergic vasculitis) have been reported. A severe allergic reaction requires discontinuation and medical management.

Contraindications to the use of Norm Skin

1. pregnancy
2. Allergy to isotretinoin or vitamin A
3. Children and infants (only by doctor’s prescription)
4. People with certain medical history such as liver problems
5. People who are allergic to the components of Norm Skin tablets.

Isotretinoin embryotoxicity

1. Do not use this product in women who are pregnant or there is a possibility of pregnancy in them. Documented fetal effects include internal and external malformations, IQ scores below 85, spontaneous abortion, premature birth, and fetal death.
2. Documented external malformations include skull malformations, ear malformations (including anotia, micropinna, small or absent external auditory canals), eye malformations (including microphthalmia), facial dysmorphia, and cleft palate.
3. Also, documented internal abnormalities include CNS abnormalities (including brain abnormalities, cerebellar abnormalities, hydrocephalus, microcephaly, cranial nerve defects), cardiovascular abnormalities, thymus gland abnormalities, and parathyroid hormone deficiency.
4. If pregnancy occurs, discontinue the drug immediately and refer the patient to an obstetrician-gynecologist experienced in reproductive toxicity for evaluation.

Side effects of Norm Skin Tablet (isotretinoin)

Dry lips and mouth, slight swelling of the eyelids or lips, peeling of the skin, nosebleeds, upset stomach or thinning hair are some of the side effects of Normskin isotretinoin. If any of these effects persist or worsen, tell your doctor or pharmacist right away. To relieve dry mouth, eat hard candy (sugar-free), ice chips, gum (sugar-free), and water. Serious side effects of this pill are psychological or creative changes (such as depression, anxiety, suicidal thoughts), tingling sensation in the skin, etc. If any of these occur, stop using and consult a doctor.

1. Dry skin, mouth and nose
2. Increased red blood cell sedimentation rate
3. Hair thinning (which has rarely persisted)
4. Desquamation of the plantar floor
5. Itching and skin fragility
6. Skin infections (such as paronychia infections)
7. Rash (including erythema, seborrhea, eczema) and sensitivity to light
8. Bone or joint pain and general muscle aches
9. Decreased bone mineral density
10. Premature epiphyseal closure

Drug interactions of Normskin (isotretinoin)

Drug interactions may change how your medications work or increase your risk of serious side effects. Make a list of the chemical and herbal medicines you use and show it to your doctor when you see him. Tetracycline drugs (such as minocycline, tetracycline), vitamin A drugs (such as acitretin, bexarotene), bone-dissolving drugs (for example, anticonvulsant drugs such as phenytoin, corticosteroids such as prednisone) cause drug interactions with Normskin tablets.

Use of Normskin (isotretinoin) during pregnancy and breastfeeding

The use and consumption of Normskin medicine during pregnancy is prohibited. If administered to a pregnant patient, it can cause fetal harm. This product will increase the risk of major congenital malformations, spontaneous abortions, and premature births following exposure to isotretinoin during pregnancy in humans. There is also a very high risk of life-threatening birth defects if you become pregnant while taking any amount of this drug, even for short periods.

If the drug is used during pregnancy or if the patient becomes pregnant while receiving treatment, the patient should be informed of the possible risks to the fetus. If pregnancy occurs during the patient’s treatment, the drug should be discontinued immediately and the patient should be referred to an obstetrician-gynecologist experienced in reproductive toxicity for further evaluation and consultation.

The effects of Norm Skin capsules on breastfeeding

There is not much information regarding the risk of Normskin tablets on nursing babies and breast milk production. Because of the possibility of serious side effects in nursing infants, patients should be advised to stop breastfeeding during treatment and for at least 8 days after the last dose.

Isotretinoin capsules and contraception

1. Patients in whom there is a possibility of pregnancy should use 2 contraceptive methods at the same time.
2. Microdose progesterone preparations (small pills that do not contain estrogen) are an inadequate method of contraception during treatment.
3. Any method of birth control can fail. Reports of pregnancy have been reported from patients using combined oral contraceptives as well as vaginal contraceptive systems, vaginal inserts, transdermal systems, and injections.
4. Physicians are advised to read the prescribing information for any medications that are administered concurrently with hormonal contraceptives. Because some drugs may reduce the effectiveness of these contraceptive products.

Storage conditions for Normskin medicine

Norm Skin (isotretinoin) should be stored at room temperature, away from light and moisture. Keep all chemical and herbal medicines out of the reach of children and animals. Dispose of this product properly when it has expired or is no longer needed. Avoid pouring all kinds of medicines into the toilet well, street and sewer.

The last word about Normskin medicine

In this article from Positive Green Online Pharmacy magazine, we have explained to you about Normskin tablets. Patients who suffer from severe acne and nodular acne must have heard the name of Rakutan (another name for Norm Skin). Isotretinoin should be prescribed with the approval and prescription of a doctor, and avoid taking it on your own without a prescription. This product has contraindications for pregnant women and children, which will threaten the patient’s health if not followed. The use of this medicine in some patients causes the exacerbation of acne, but after one to two months, the patient will recover.

Site source: Medscape

Frequently asked questions about norm skin