Structural gene, new methods of diagnosis and treatment

Cancer has created many problems for mankind since its inception. In most cases, cancer complications are caused by genetic instabilities. Today, with the significant advancement of technology and the fruitful research of medical sciences, not only the causes of that horrible disease can be found, but they will also be able to perform better in early diagnosis and prevention of its occurrence.

Gene therapy is a promising solution for the treatment of a wide range of diseases with genetic origin. In Iran, good measures have been taken in the field of gene therapy, but it is still at the beginning of its dynamic scientific path. Gene Sazeh Company will also be a provider of services in the field of genetics and production of genomics products, for that reason Ecomotive’s conversation with the CEO of Gene Sazeh Company Amen follow:

Please introduce yourself to your contacts and tell us about your work background.

Mr. Reza Shahbazi, I am a graduate of the master’s degree in medical engineering, I have started my work experience from manufacturing companies active in the field of medical equipment and health services. On the other hand, we are supposed to be active in the field of genetic products and services in Sazeh Gene Collection.

Where did the structure gene start?

Gene Sazeh company was established in the summer of 2019. Gene Sazeh Company will provide services in the field of genetics and production of genomics products. This company is a platform through which we can do commercial and technological work with technology and research teams, academic centers, research centers and also companies active in the field of recombinant drugs.

In fact, we want to do technological and innovative work with the collections that are active in the field of providing genomics services.

Gene Sazeh was formed to solve what problems?

The issue of the corona pandemic has caused us to realize many unresolved problems in our country. In this way, we can carry out measures in the field of genetic investigation of pathogenic agents, and this means timely diagnosis by doctors and the development of treatment methods. In this way, medical centers and patients can benefit from the latest science used in the developed countries of the world.

Gene Sazeh actually facilitates and prepares a new generation in the field of diagnosis and treatment, which does not exist in the country. For this purpose, it wants to be a platform for new technologies to enter the country.

Has passing personal experience in this field led to the launch of Gene Maker?

No, I have come across such issues mostly in work fields. At present, the people who are engaged in the activity of structural genes have noticed the lack of handling of this type of concerns in the country, and suggestions regarding the formation of a group that can bring technological infrastructures in the field of genomics to the country have been sent to the headquarters group. They have presented the implementation of Imam’s (RA) decree.

What does genomics mean?

The field of genomics in the world has a lot of scope, including: treatment issues, finding talents, nutritional regimes, sports, modifying the structure of plants, plants and animals.

What is gene therapy?

The main basis of all diseases in the world depends on genetics. If we can identify and offer a solution to treat it, we will be able to make medicine and vaccines that deal with the disease in terms of genetic structure. On the other hand, people generally get cancer as a result of a change in their genetic nature, if it is possible to identify that change in time and analyze and investigate it, we will eventually be able to design vaccines to prevent the occurrence of cancer. The solution can be found in the HPV vaccine.

HPV infection is a viral infection that often causes skin or mucosal warts. Cancer caused by the HPV virus is very rare in men and mainly affects women in the field of cervical cancer. Today, the HPV vaccine has been genetically analyzed and tested and has passed the clinical trial stages, so it is a good way to prevent cervical cancer in women.

HPV vaccine has recently entered Iran and is in the commercial stage. On the other hand, in relation to the conditions after contracting the disease, we are looking for measures to silence the patient’s gene.

What are the problems of gene therapy?

Gene therapy is a new technology in the world that moves at the frontier of knowledge. Therefore, it is natural that there are strictures to it from the regulatory aspect and obtaining permits. We also use the experiences of previous treatments, for example, early when recombinant drugs entered the market, there was not much knowledge about them, for the same reason, they went through long processes to obtain relevant licenses until then. which have entered the consumption and treatment market. In the field of gene therapy, the procedure is the same, and we are facing problems at the beginning of our work.

What measures have you taken for the safety of clinical trials and gene therapy research?

Gene therapy, like other processes in the country, must pass difficult tests in three levels of basic research, animal and human models, in order to enter the market and receive a license. Therefore, in the early stages, it should be pre-clinical and then it should pass the human clinical stages. Finally, if the necessary approvals are obtained, the relevant license will be issued.

How should those who wish to participate in clinical trials proceed?

In order to enter medicine and vaccines for clinical trials in the health and commercial market of the country, they must first go through the necessary protocols for the approval of the Food and Drug Organization, and for its implementation, calls are made for volunteers to participate in the trials.

What fields are your team members working in?

One of the goals of our company is to work in the field of genome sequencing, for that reason we intend to provide services in that field to patients and medical centers. Another part of our activity is in the field of gene synthesis, a part of which is related to genomics products and is used in the production of diagnostic kits that are designed and produced for the use of medical and research centers. After that, we will be active in the field of producing technical knowledge of drugs based on genetic products in the field of gene therapy.

What skills do your team members have?

Our team consists of various specialties including: genetic engineering, bioinformatics and biotechnology. All the members of our team have completed their university education in connection with their specialization, therefore they have been added to the Gene Sazeh collection in order to guide and advance our goals.

What difficulties have you faced in starting your business?

At present, due to the initial preparation of the structural gene infrastructures and the lack of production of products, we have not yet faced the basic difficulties of our field of work, for the same reason, we have not had experience in facing those challenges.

From your point of view, what obstacles does the health field face?

The problems and difficulties of the health system are not hidden from anyone, but considering that gene therapy is a new science in our country and we are at the beginning of the path, we have no preconceived notions about the possible problems that may arise in the coming years. .

How has your business investment process been?

Barkat Knowledge Foundation Institute This made it possible for the executive headquarters of Farman Imam (RA) to create an infrastructure to carry out technological activities in the field of genetics with other research and technological teams by investing in this company.

Do you have a competitor in your field of activity?

Naturally, we are not the only group active in this field. Other companies are also forming in the field of gene therapy and providing genomics services, and we will have a constructive and dynamic competition with them.

What plans do you have in mind to develop your business?

In the field of genome sequencing in the field of cancer, as well as sequencing of specific patients, we have defined panels based on which we can provide a variety of services.