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Axar tablets | Review of uses and side effects

September 19, 2023

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Axar or Oxedrin is a drug combination that contains acetaminophen, aspirin and caffeine. Acetaminophen in this combination reduces fever and pain. Aspirin is also a salicylate drug that helps to treat it by reducing the symptoms of pain, fever and inflammation. The caffeine in this composition also improves blood flow by reducing the contraction of blood vessel muscles. In general, Axar is used to treat various pains such as tension headaches, colds, migraine headaches, muscle pain, menstrual cramps, arthritis, toothache and nasal congestion. Stay with Green Positive to get the necessary knowledge of the medicinal information of this drug.

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Pharmaceutical forms of Axar

This medicine is available in the form of tablets, and each tablet contains 162.5 mg of acetaminophen, 325 mg of aspirin and 32.5 mg of caffeine.

Uses of tablets Axar

Axar tablets contain a combination of acetaminophen, acetylsalicylic acid and caffeine. This pill is used to relieve body pain and fever. Acetaminophen and acetylsalicylic acid are the two active ingredients in this pill, which are used to relieve mild to moderate pain, especially migraine headaches, due to their analgesic properties. Also, the caffeine present in this pill can reduce cold-related complications such as dizziness.

Pharmacological effects and mechanism of action of Axar drug

“Pharmacological effects and mechanism of action” generally refers to the effect of a drug or chemical substance in the body and how it acts on different cells, tissues or biological systems. These effects include the absorption, distribution, metabolism and excretion of the drug in the body, as well as its effects on different cells and tissues.

The mechanism of action of drugs refers to how they affect the biological systems of the body. For example, some drugs can interact with specific proteins in cells and alter biological processes, while other drugs can interact with cell surface plates and alter the activity of cellular processes. Their ultimate goal is to control or relieve symptoms or various diseases.

Axar tablet is a medicine to relieve joint and bone pain that has an anti-inflammatory effect. Acetaminophen binds to plasma protein to a very low extent and aspirin to a very large extent. The peak plasma concentration of aspirin is 1-2 hours and acetaminophen is 2-5 hours after consumption. All these compounds are excreted through the kidneys.

By inhibiting the activity of cyclooxygenase 1 and 2 enzymes, this drug reduces the production of inflammatory prostaglandins and thus helps to reduce inflammation and pain. Also, Axar inhibits the action of therapeutic leukotrienes and blocks the release of histamine from tissue cells, which reduces swelling and joint and muscle pain. Also, this medicine has the ability to reduce fever.

Dosage of Axar tablets

Axar tablets are usually taken when needed. The dosage depends on the prescription of the specialist. If you accidentally miss a dose, it is best to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and return to your regular schedule. Adhering to the timing of taking medicines is very important to control the disease. If you are taking a certain medicine, it is better to pay attention to the timing and exact amount of doses. The dosage of this drug is generally as follows:

As an antipyretic or pain reliever, 1-2 tablets every 3 or 4 hours

Time to take Axar tablets

The time of taking this medicine should be determined by the doctor. This medicine should not be taken at the following times:

The first trimester of pregnancy is not the right time to take Axar tablets.
In case of intolerance to salicylate and non-steroidal anti-inflammatory drugs (NSAIDs), you should avoid taking Axar tablets.
Do not use this pill if you have undergone surgery or are suffering from influenza, favism or chicken pox.
You should consult your doctor if you are taking anticoagulants or drugs that affect blood clots at the same time.
Avoid drinking alcoholic beverages while you are using Axar tablets.
For those suffering from heart disease, kidney disease, liver failure, digestive problems or high blood pressure, according to the type of disease and its severity, taking Axar tablets is prohibited.
Be careful if you are allergic to aspirin or caffeine.
If you have severe side effects, such as severe bleeding, abdominal pain, blood in stool, etc., inform your doctor.

Precautions

Stop taking Axar if you experience the following:

Anxiety and severe pain:	If you experience severe pain along with anxiety, this may be a sign of a serious problem.
Unusual bruising or bleeding:	If you suddenly experience unusual bruising, bleeding, or excessive bleeding, this is a sign of bleeding problems that require immediate evaluation and treatment.
Lightheadedness:	If you feel very lightheaded and dizzy, it is due to blood pressure problems or effects on the nervous system.
Symptoms of kidney failure:	If you feel very thirsty, too hot, unable to urinate, sweat a lot, have dry or warm skin, it is a sign of serious kidney problems or water and electrolyte metabolism.
Symptoms of abdominal bleeding:	If you have dark stools, cough up blood, vomit with brown seeds, or abdominal bleeding, it is a sign of internal bleeding problems in the digestive system.
Symptoms of high potassium:	If you experience a slow heart rate, weak pulse, muscle weakness, and a shaky feeling, this may be a sign of high blood potassium, which is a serious problem.
Liver problems:	If you experience nausea, pain in the upper abdomen, itching, loss of appetite, and dark urine, this is a sign of liver problems and requires immediate treatment.

Oxar contraindications

If there are conditions such as hemophilia, anaphylaxis, angioedema or severe allergic reactions to aspirin or NSAID drugs, aspirin should not be continued with the possibility of bleeding.
When you are allergic to ACE tablets.
You are pregnant or breastfeeding or planning to become pregnant.
You are facing anxiety disorders.
You have a chronic insomnia problem.
You have asthma or are sensitive to aspirin
You have a history of worsening breathing with a runny or stuffy nose after taking aspirin or other NSAIDs such as ibuprofen, naproxen.
You have nasal polyps.
Heart problems such as arrhythmia. you have.
You have blood disorders or anemia.
You have bleeding or clotting problems, such as hemophilia or a low platelet count.
You have stomach discomfort such as heartburn or stomach pain.
You have gout, liver, kidney or digestive problems.
You do not control your diabetes.
You have high blood pressure or a part of your body is injured.
Do you smoke or use other drugs?
You should not take aspirin if you are at risk of bleeding or have hemophilia, a genetic bleeding disorder. Also, avoid taking aspirin if you are highly allergic to aspirin or other NSAIDs and bleeding ulcers.
In case of symptoms of anaphylaxis such as shortness of breath, swelling of the face or lips, severe abdominal pain, low blood pressure or shortness of breath after taking aspirin, consult a doctor immediately.

Axar side effects

Side effects associated with severe reactions in the body:

Hives: If your skin turns yellow or has a hives color, this may be a sign of serious liver problems.

Breathing problems: If you have severe breathing problems such as difficulty breathing, flu, or wheezing, this is a sign of a serious allergic reaction.

Swelling of the face, lips, tongue or throat: Swelling in these areas indicates that you have the flu or difficulty swallowing, this can be a sign of a severe allergic reaction. In rare cases, taking acetaminophen causes severe skin reactions.

Common side effects of Axar:

Abdominal pain: Some people may experience pain or tightness in the abdominal area after taking Axar. If this condition is uncomfortable for you or becomes more severe, it is better to consult your doctor.
Heartburn: Taking Axar may cause burning or infection in the hearth area. If this complication occurs, it is better to stop taking Axar tablets.
Depression, anxiety or restlessness: Some people experience changes in mood after taking Axar.
Sleep problems: Some people may experience sleep problems such as waking up at night, insomnia, or sleeping too much after taking Axar.

Axar tablets for fever

Axar drug interactions

Drug interactions of Axar tablets can change the way the drugs work and bring the risk of side effects. In the following, we will refer to additional items.

Drugs toxic to the liver:

Axar tablets may interact with drugs that are toxic to the liver. This interference can affect liver function and cause serious complications for liver health.

Drugs that stimulate the central nervous system:

Axar tablets interact with drugs that stimulate the nervous system. The side effects of this interference change the nerves and the psyche and increase anxiety, anger or sleepiness.

Lithium:

Simultaneous use of Axar tablets interacts with lithium and affects the blood lithium level and causes serious side effects.

Antidepressants and monoamine oxidase inhibitors:

Axar may interact with antidepressants, especially monoamine oxidase inhibitors. This interaction alters the effects of antidepressants and increases the risk of side effects such as seizures, increased blood pressure, and other cardiac complications.

Medicines containing acetaminophen and aspirin:

Axar tablets may interact with acetaminophen, aspirin or drugs containing them. This interaction increases the risk of stomach and intestinal complications and aggravates the complications of bleeding or stomach and intestinal injuries.

Non-steroidal anti-inflammatory drugs:

Axar interacts with non-steroidal anti-inflammatory drugs. This interaction can affect the stomach and intestines and cause bleeding.

Glucocorticoids:

This interaction can aggravate the side effects associated with the use of glucocorticoids. Such as increased blood pressure, changes in blood sugar levels, muscle weakness and other complications related to the hormone cortisol.

Combined medicines and herbal teas:

Simultaneous use of Axar tablets and combined drugs and herbal teas brings unwanted side effects

It is best to give your doctor a detailed list of the medications you are taking so that he can check for possible drug interactions and provide the necessary guidance.

Taking Axar tablets during pregnancy and breastfeeding

It is not allowed to take Axar tablets during pregnancy. Only when the doctor has confirmed the necessity of its use and its benefits outweigh its side effects, you can take this pill for a short period of time. Receiving the three medicinal substances acetaminophen, aspirin and caffeine during pregnancy, for a long time and in high doses, may have serious side effects. This issue applies especially in the last trimester of pregnancy and many doctors recommend that this drug be used only in very special and necessary conditions during this period due to the side effects of Axar tablets in pregnancy.

Axar drug storage conditions

Axar tablet is a medicine that requires a temperature of 15 to 30 degrees Celsius for storage. Therefore, this medicine should be kept in a dry and cool place. The medicine should not be exposed to the air. On the other hand, if you smell vinegar in the pill, you should not use it anymore. Keep the medicine out of the reach of children and animals.

The difference between aspirin and Axar tablets

Aspirin and Axar tablets both contain acetylsalicylic acid, which has analgesic, antipyretic, anti-inflammatory properties and prevents blood clotting in the veins. However, the difference between these two drugs is that aspirin is used periodically and in low doses to prevent blood clots. While Axar tablets are mostly used to reduce pain and fever. Axar tablets may also cause stomach irritation. Therefore, it is not recommended for people with stomach problems.

The last word about Axar tablets

As we said in this article from Positive Green Pharmacy magazine, Axar tablets contain acetaminophen, aspirin and caffeine and reduce fever and pain. This drug can also be used to reduce inflammation and improve blood flow in the body. If you have any questions about this medicine, leave us a comment.

Site source: Medscape