What is Cortam? Uses and side effects of clobetasol ointment

In the world of medicine and treatment, ointments are very important as one of the vital tools for treating skin and inflammatory problems. One of the most important and important ointments in this field is Kortam ointment. Cortam drug is used as a medicinal compound with anti-inflammatory and anti-allergic effects in the treatment of skin and inflammatory problems. The uses of this ointment are very wide in the external (skin) parts of the body, but it is not applicable in the internal parts of the body such as the nose, ears, mouth, etc. In the following, we will examine the medicinal forms, uses, method of use, cautions and contraindications of clobetasol.

Pharmaceutical forms of Cortam (Clobetasol)

The dosage forms of Cortam include topical cream 0.025% (Impoyz) and 0.05% (Transfer), topical foam 0.05% (Olux, Olux E), topical gel 0.05%, topical lotion 0.05% (Clobex), topical ointment 0.05% (Transfer), There are 0.05% local shampoo (Clobex shampoo, Klodan shampoo, Klodan kit), 0.05% topical solution and 0.05% topical spray (Clobex spray).

Uses of Cortem Ointment

Cortam drug is used to treat various skin diseases (such as eczema, psoriasis, dermatitis, allergies, skin rashes). Clobetazole (Cortam) reduces the swelling, itching, and redness that can occur in these types of conditions. Cortam is a very strong corticosteroid. Some of the most important uses of this drug include corticosteroid-responsive dermatoses, scalp psoriasis, plaque psoriasis, etc.

Uses of cortam in adults

1. Corticosteroid-responsive dermatoses
2. Psoriasis of the scalp
3. Plaque psoriasis

Uses of cortam in children

1. Corticosteroid-responsive dermatoses
2. Psoriasis of the scalp
3. Mild to moderate plaque psoriasis on non-scalp areas
4. Dermatoses of the scalp responsive to corticosteroids

Pharmacological effects and mechanism of action of clobetasol drug

Corticosteroids reduce inflammation by stabilizing leukocyte lysosomal membranes and prevent the release of destructive acid hydrolases from leukocytes. Inhibiting the accumulation of macrophages in inflamed areas, reducing the adhesion of leukocytes to the capillary endothelium, reducing capillary wall permeability and edema formation, reducing complement components, conflicting with histamine activity and the release of kinin from substrates, and reducing fibroblast proliferation, collagen deposition and subsequent scar tissue formation through the drug. Kurtam takes place. Finally, it is excreted through urine and feces.

Dosage of clobetasol ointment

Cortam drug (clobetasol) is used for use on the skin of the body and its use in the internal parts of the body such as the nose, ears, mouth, etc. is prohibited. Also, do not use this medicine on the face, groin or armpits, unless the doctor deems it necessary to do so. Wash and dry your hands before use, then clean and dry the affected area. Apply a thin layer of the medicine to the affected area and gently massage as directed by your doctor, usually 2 times a day. After using the ointment, do not cover the desired area with a bandage or tissue and allow the medicine to work.

Time to use Cortem Ointment

Wash your hands after using Cortam unless you are using it to treat your hands. When using this medicine near the eyes, avoid getting it into the eyes as it may worsen or cause glaucoma. Also, avoid putting this medicine in the nose or mouth. If you get the medicine in these areas (eyes, mouth, nose or ears), rinse with plenty of water. Use this ointment only for prescribed conditions. It is also forbidden to take this medicine for more than two consecutive weeks or more than 50 grams per week.

How to use Kortam ointment in adults

1. This drug is used to relieve inflammatory manifestations and itching of corticosteroid-responsive dermatoses. To use Kortam cream, apply a thin layer on the affected areas every 12 hours, and the total amount of medicine should not exceed 50 grams per week. Apply the lotion of this medicine on the affected areas of the skin and massage the area slowly and thoroughly.
2. If you intend to use this medicine on the scalp, apply the foam to the affected area of ​​the scalp every 12 hours for 2 weeks.
3. This medicine is used for moderate to severe types of scalp psoriasis. Apply a thin layer of Kortam shampoo on dry scalp. Leave it in place for 15 minutes and add water until it foams and then rinse. Consider limiting treatment to 4 consecutive weeks due to drug’s potential to suppress the hypothalamic-pituitary-adrenal (HPA) axis.
4. For mild to moderate plaque psoriasis, apply the foam to the affected area of ​​the scalp every 12 hours for 2 weeks. Be careful that the total consumption should not exceed 50 mg.
5. The emollient cream or lotion of this drug should be used on the affected area for 2 weeks (cream) or up to 4 weeks if needed (emollient cream, lotion) when the use is less than 10% of the body surface. Treatment with lotion for more than 2 weeks should be limited to localized lesions (less than 10% body surface area) that have not improved adequately with treatment. Also, not more than 50 grams or 50 ml per week.
6. Cortam spray is recommended for the treatment of moderate to severe plaque psoriasis affecting up to 20% of the body surface area (BSA). Use this medicine by spraying on the affected area every 12 hours. Spray treatment for more than 2 weeks should be limited to localized lesions that have not healed adequately.
7. Note that 0.025% cream is not recommended for treatment for more than 2 consecutive weeks and the total dose should not exceed 50 g/week because this drug may suppress the hypothalamic-pituitary-adrenal (HPA) axis.
8. Clobex Lotion, 0.05% should not be used with occlusive dressings. Also, it should not be used on the face, armpits or groin, and should not be used if there is atrophy in the treatment area.
9. clobetasol shampoo has limitations and should not be used on the face, groin or armpits. Avoid any contact with eyes and lips, and in case of contact, wash all parts of the body that came into contact with the shampoo with water.

How to use Kortam ointment in children

1. Corticosteroid-responsive dermatoses in people over 12 years old (cream/foam), apply a thin layer to the affected areas and massage gently and thoroughly. Also, the safety and effectiveness of this drug in children under 12 years old has not been proven.
2. For corticosteroid-responsive scalp dermatoses, in people over 12 years of age (foam) should be used on the affected area of ​​the scalp every 12 hours for 2 weeks. Total intake should not exceed 50 grams or 50 ml per week.
3. For scalp psoriasis in people over 12 years old (shampoo), apply a thin layer to dry scalp daily and leave on for 15 minutes, then rinse and rinse.
4. Mild to moderate plaque psoriasis on non-scalp areas, in people over 12 years of age, use for 2 weeks on the affected area of ​​the scalp every 12 hours.

Precautions

Before using Cortam (clobetasol), if you are allergic to it or other corticosteroids (such as hydrocortisone, prednisone), avoid using it. Consult a pharmacist or doctor regarding allergic reactions or sensitivities to this medication. Use with caution if you have medical history, including poor blood circulation, immune system problems, some skin diseases (rosacea, dermatitis around the mouth), severe wounds at the application site, infection at the application site, etc.

Also, rarely, using corticosteroid medications for long periods of time or on large areas of the skin can make it harder for your body to respond to physical stress.

1. Chronic topical corticosteroid therapy may interfere with growth and development in children.
2. This drug may cause hypercortisolism or suppression of the hypothalamic-pituitary-adrenal (HPA) axis, especially in younger children or patients receiving high doses for long periods.
3. use less power in children; It may absorb larger amounts after topical application, causing systemic effects. Treatment is not recommended in children under 12 years of age. Long-term use may affect growth rate (routinely monitor growth in pediatric patients). Clobex lotion, Clobex spray, Clobex shampoo, Clodan shampoo are not recommended for use in patients under 17 years of age.
4. Kaposi’s sarcoma has been reported with long-term corticosteroid therapy. If this occurs, consider discontinuing treatment.
5. Percutaneous absorption of corticosteroids may cause manifestations (complications) of Cushing’s syndrome.
6. Topical corticosteroids increase the risk of glaucoma and posterior subcapsular cataract. Glaucoma and cataracts have been reported in post-marketing reports. In case of eye contact, advise patients to report any visual symptoms.
7. The foam dosage form is flammable, avoid fire, flames, or smoking during and immediately after use.
8. Local effects including perioral dermatitis, acne breakouts, folliculitis, hypopigmentation, skin atrophy, miliaria, secondary infection and telangiectasia occur in some patients.
9. Concomitant skin infections may be present or develop during treatment. Discontinue treatment if skin infection persists after antimicrobial therapy.

Contraindications to the use of Cortam

1. Viral, fungal or tuberculosis skin lesions
2. Hypersensitivity
3. Eye use

Side effects of Cortam (clobetasol)

Burning, itching, hives, redness or swelling are some of the side effects of Cortam (cream, ointment, lotion, gel, etc.). These side effects should go away within a few days as your body adjusts in some cases. Most people who use Cortam do not experience serious side effects. Some of the serious side effects of this drug include stretch marks, thinning or discoloration of the skin, acne, severe or unwanted hair growth, small red bumps on the skin (folliculitis), etc. If redness, swelling, or burning does not improve, tell your doctor right away.

1. Atrophy of the skin
2. Telangiectasia
3. skin discomfort
4. dry skin
5. Atrophy of the skin
6. stretch marks
7. Burning
8. Cracks or fissures in the skin
9. Erythema
10. folliculitis
11. Stimulation
12. numb
13. itching
14. According to the post-marketing reports of these drugs, various side effects such as striae, irritation, dryness, acne-like pimples, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis and miliaria have been reported in (limited) patients.

Cortam drug interactions

1. Class X interactions (avoid): aldesloquine
2. Reduction of the effects of drugs by clobetasol: aldesloquin, corticorelin, hyaluronidase
3. Increased effects of drugs by clobetasol: deferasirox, ritodrine
4. Reduction of effects of clobetasol by drugs: No significant drug interactions have been reported.

Taking Cortam (clobetasol) during pregnancy and breastfeeding

No specific information is available on the use of Cortam in pregnant women. Published data report a significant increase in the risk of low birth weight with the use of 300 g of strong or very strong topical corticosteroids during pregnancy. Warn pregnant women about the possible risks to the fetus and the use of this medicine in the smallest area of ​​the skin and in the shortest possible time. Also, in animal reproduction studies, an increase in malformations (such as cleft palate and skeletal malformations) after SC administration clobetasol It was observed in pregnant rats and rabbits.

The effect of cortam drug on breastfeeding

No information is available on the presence of clobetasol in breast milk or its effects on the nursing infant or milk production. Administered corticosteroids appear systemically in human milk and can suppress growth, interfere with endogenous corticosteroid production, or cause other adverse effects. It is also unclear whether topical administration of clobetasol can result in sufficient systemic absorption to produce detectable amounts in human milk, but to minimize potential risk to the infant through breast milk, clobetasol should be applied to the smallest area of ​​skin and Use as soon as possible during breastfeeding.

Storage conditions for clobetasol ointment

Cortam cream (clobetasol) should be stored at room temperature (room temperature not refrigerator) and away from light. It is also important to keep all medications out of the reach of children, as many forms of medication (such as weekly tablets and eye drops, creams, patches, and inhalers) are not child-resistant and can be easily opened by young children. . Unnecessary medications should be disposed of in specific ways to ensure that pets, children, and other people cannot ingest them.

The last word of the drug Kortam

Considering that Kortam ointment is known as an effective therapeutic tool in dealing with skin problems, it is recommended that dermatologists and doctors, as the main agents in prescribing the use of this ointment, use their full precision in prescribing the appropriate dosage. take This medicinal combination with its anti-inflammatory and anti-allergic effects is a powerful solution in the treatment of skin problems and can help people improve their quality of life and skin health. We have described this article with the title of clobetasol cortam drug from the online pharmacy magazine Positive Green.

Site source: Medscape