What is Glibenclamide?

Glibenclamide tablets are used for diabetics. This medicine is used as a new initiative in fighting some diseases and complications of type 2 diabetes. The mechanism of action of Glibenclamide tablets stimulates and releases more insulin from the pancreas. Insulin is a hormone that is secreted from the pancreas and controls the patient’s blood sugar level. In the following, we will examine the medicinal forms, uses, precautions and contraindications of this medicine.

Glibenclamide pharmaceutical forms

Glibenclamide is produced in tablet form and is available in the market. This drug belongs to the group of sulfonylurea, which was produced for the first time in 1966, which is also known as glyburide.

Glibenclamide uses

Glibenclamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (a condition in which the body does not use insulin normally and therefore cannot control blood sugar levels). This drug is in a class of drugs called sulfonylureas. The ingredients in this drug lower blood sugar by making the pancreas produce insulin (a natural substance needed to break down sugar in the body) and help the body use insulin more effectively. This drug only helps lower blood sugar in people whose bodies naturally produce insulin.

Pharmacological effects and mechanism of action of glibenclamide drug

Glibenclamide reduces blood glucose in non-insulin-dependent diabetes mellitus by directly stimulating insulin secretion from pancreatic beta cells. Also, long-term use of sulfonylurea drugs increases insulin sensitivity in some tissues such as liver, muscle, etc., which results in a decrease in glycogenolysis and gluconeogenesis in the liver.

Dosage of glibenclamide

Over time, people with diabetes and high blood sugar can experience serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (such as diet, exercise, quitting smoking), and checking your blood sugar regularly may help manage your diabetes and improve your health. This treatment may also reduce the chance of having a heart attack, stroke or other diabetes-related complications such as kidney failure, nerve damage (numbness, cold feet or legs, decreased sexual ability in men and women), eye problems, including changes Reduce.

How to use Glibenclamide

1. Take Glibenclamide exactly as your doctor has told you. The usual starting dose for adults is 5 mg per day. This medicine is prescribed as a single dose to be taken with breakfast or immediately after.
2. The dose for a child will vary depending on their body weight and more than once a day may be needed. Follow your doctor’s instructions carefully.
3. If you (or your child) have been given oral liquid medication, be sure to measure the correct amount using the oral syringe and adapter provided. Follow the instructions printed in the manufacturer’s brochure.
4. If you are giving oral liquid medicine to the baby, it should be given about 15 minutes before feeding.
5. If you miss a dose, take it as soon as you remember. If you do not remember until the next day, skip the missed dose. Do not take two doses in one day to make up for a missed dose.

Time to take Benclamide tablets

Before taking any medication, first read the medication information on the product package. The manufacturer has told you how and when to take Glibenclamide for general use. This medicine comes as an oral tablet and is usually taken once a day with breakfast or the first main meal of the day. However, your doctor may prescribe you to take 2 tablets a day. This drug helps control blood sugar but does not cure diabetes. If you feel cured after taking it, do not stop taking the medicine without consulting your doctor.

Precautions

Before taking glibenclamide, if you are allergic to this drug or its other ingredients, avoid using it. This medicine may contain inactive ingredients that may cause side effects and allergies in you after use. People with medical records such as a history of sensitivity to sulfonamides, liver and kidney failure, weak and elderly patients, malnutrition, adrenal insufficiency, autonomic neuropathy (because they notice the symptoms of hypoglycemia later), G6PD deficiency (favism), heart disease, and users of heart medications. And… use with caution.

1. Tell your doctor if you have or have ever had G6PD deficiency (an inherited condition that causes premature destruction of red blood cells or hemolytic anemia).
2. People with hormonal disorders related to the adrenal gland, pituitary or thyroid, heart, kidney or liver disease, pregnant women and nursing mothers should take this medicine with the advice and prescription of a doctor.
3. People 65 years of age or older, talk to your doctor about the risks and benefits of taking this drug. Elderly people should not usually take glibenclamide because it is not as safe or effective as other drugs that can be used to treat the same condition.
4. Ask your doctor about the safe use of alcoholic beverages while taking Glibenclamide. Alcohol can increase the side effects of this drug. Also, in some limited cases, alcohol consumption has caused symptoms such as flushing (redness of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, suffocation, breathing problems and anxiety.
5. Plan to avoid unnecessary or prolonged sun exposure. Because light sensitivity has been reported in some patients.

Recommendations for the use of benclamide tablets

1. After prescribing the prescription and taking it, be sure to visit the doctor at least one more time to evaluate your illness.
2. If your doctor has advised you to change your diet, quit smoking or exercise regularly, it is important that you follow the advice given.
3. Low blood sugar (hypoglycemia) can occur if you miss a meal, exercise more than usual, get sick, or drink alcohol.
4. Do not drink alcohol, as it can affect your blood sugar control. If you need more guidance on this matter, ask your doctor.
5. If you plan to drive after taking this medicine, you should be careful. Because if your diabetes is not well controlled, your ability to concentrate may be affected.

Contraindications for Glibenclamide

1. History of allergy to this drug (glibenclamide) or other sulfonylurea drugs
2. Type 1 diabetes
3. In some cases, such as acidosis, severe burns, diabetic coma, hyperosmolar non-ketonic coma, severe stress, trauma, surgery, severe liver and kidney diseases and porphyria.
4. Pregnancy and breastfeeding
5. Your customers

Glibenclamide side effects

This medicine may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms. Nausea, upper abdominal fullness, heartburn, hives, light-colored stools, dark urine, pain in the upper right side of the stomach, unusual bruising or bleeding, diarrhea, fever, and sore throat are some of the most important side effects of glibenclamide. If these symptoms persist or worsen after stopping the medication, see your doctor. Also, this drug may cause other side effects in some patients. Contact your doctor if you experience any unusual problems while taking this medicine.

1. nausea
2. Upper abdominal fullness
3. heartburn
4. urticaria
5. Light colored stools
6. dark urine
7. Pain in the upper right side of the stomach
8. Unusual bruising or bleeding
9. diarrhea
10. Fever
11. Sore throat
12. Swelling of the eyes, face, lips, tongue, or throat

Glibenclamide drug interactions

1. Concomitant use: aminolevulinic acid (systemic), bosentan, mecamylamine, mitiglinide
2. Moderate interactions: chlorthalidone, cimetidine, clarithromycin, clofibrate, colsulam, cyclosporine, dipotassium glycyrrhizate, eltrombopag, empagliflozin, enalapril, enalaprilat, esmolol, eucalyptol, isocarboxazid, labetalol, levonolol, licorice, linagliptin, linezolid, lisinopril, methylene blue, methyl Pranolol, metolazone, Metoprolol, mifepristone, moclobamide, moexipril, nadolol, nebivolol, nialamide, xprenolol, penbutolol, perindopril, phenelzine, pindolol, polythiazide, proctolol, pramlintide, probenecid, procarbazine, propranolol
3. Increasing the effectiveness of drugs by glibenclamide: ajmaline, alcohol (ethyl), aminolevulinic acid (systemic, local), bosentan, carbocysteine, cyclosporine (systemic), hypoglycemic drugs, mecamylamine, porfimer, vertporfin, vitamin K antagonists
4. Major interactions: Aspirin, fluoroquinolones, chloroquine, darulotamide, desmopressin, disopyramide, dolaglutide, enacidinib, encorafenib, enoxan, entacapone, flumoquine, hydroxychloroquine, lanreotide, ligasenatide, metraleptin, midostarine, octreotide, pazeireotide, pioglitazone, porfimer, simprovir , sitagliptin, sodium Thioctate, triflunomide

Storage conditions for glibenclamide

Glibenclamide should be stored at room temperature and away from light and moisture. Also, keep different medicines away from children and animals.

The last word of Glibenclamide drug

In this article from Positive Green Online Pharmacy magazine, we have explained to you about Glibenclamide drug. Finally, it should be said that excessive and long-term use of glibenclamide tablets reduces insulin resistance. In this regard, doctors sometimes prescribe this drug with metformin tablets, because the combination of these two drugs simultaneously stimulates the pancreas to produce more insulin and reduce the sensitivity of the body’s cells to insulin. Doctors use less glibenclamide in some overweight and obese patients, because this drug will cause weight gain.

Site source: Pubmed