What is Urinacin or Solifenacin?

Urinary tract disorders are common problems faced by many people around the world. These disorders can be caused by various causes including inflammation, chronic pressure, strictures and even genetic factors and have different effects on the quality of life of a person. Among the complications of these disorders, we can mention the lack of control of access to the early and middle stages of the urinary system, strictures, and the infiltration of water and electrolytes into the surrounding tissues. In this article, we will review the performance and applications of solifenacin in urinary tract disorders.

Pharmaceutical forms of Urinacin

Urinacin is available in 5 mg (VESIcare) and 10 mg (VESIcare) tablets. Drugs of its group also include darifenacin, flavoxate, oxybutynin chloride, toltrodine, trospium chloride, fesotrodine, mirabegron.

Uses of Urinacin

Solifazine is used to treat overactive bladder and improves your ability to control urination by relaxing the bladder muscles. This medication helps reduce urinary leakage, the feeling of having to urinate urgently, and frequent trips to the bathroom. This drug belongs to the category of drugs known as antispasmodics. The most important uses of Urinacin include the treatment of overactive bladder, frequent urination and urinary incontinence.

Pharmacological effects and mechanism of action of solifenacin

The mechanism of action of Urinacin reduces bladder contractions, increases the volume of urine remaining in the bladder and reduces pressure on the detrusor muscle (by competitively antagonizing muscarinic receptors). absorption in the maximum plasma concentration of the tablet, 32.3 ng/ml (5 mg dose); 62.9 ng/ml (10 mg dose) and for its solution it is 2.5-29 ng/ml. Also, this drug is extensively metabolized by the liver, mainly by CYP3A4. Finally, it is excreted through urine (69%) and feces (23%).

Dosage of solifenacin

Before taking Urinacin, read the drug information on the drug package. The manufacturer of the drug has stated the amount and time of use for the patients. Take this medication orally with or without food as directed by your doctor, usually once a day. Take the pill with a glass of water to avoid problems in your stomach and digestive system. Swallow the tablet whole, because the powder in the tablet has a bitter taste. If you are using the liquid form of this medicine, shake the bottle well before each use.

Time to take Urinacin

Use a special measuring device or spoon to take the medicine dose accurately. It should be noted that you should not use a homemade spoon because you may not get the right dose. Avoid taking the liquid form with food or other beverages, as it may produce a bitter taste. Consult your doctor regarding the medication you are taking (chemical or herbal) so that he can reduce the dosage or stop your medication if needed.

How to take Urinacin

1. Solifenacin is recommended for the treatment of overactive bladder (OAB) with symptoms of urge incontinence, urgency, and frequency. The recommended dose is 5 mg per day, which may be increased to 10 mg per day if the patient tolerates it.
2. People with mild to moderate renal impairment (CrCl ≥30 ml/min), do not need to readjust the dose, but in severe renal impairment, the use of the drug should not exceed 5 mg per day.
3. The use of this drug is recommended for the treatment of neurogenic detrusor hyperactivity (NDO) in children over 2 years old. For children from 9 to 15 kg 2 ml per day not exceeding 4 ml per day, children from 15 to 30 kg 3 ml per day not exceeding 5 ml per day, persons from 30 to 45 kg 3 ml per day not exceeding not more than 6 ml per day and in people 45 to 60 kg 4 ml per day, not more than 8 ml per day.
4. Also, the recommended dose for people over 60 kg is 5 ml per day at the beginning of treatment, which should not exceed 10 ml per day.

Precautions

Before using solifenacin, if you are allergic to it or any of its ingredients, avoid using it. This medicine may contain inactive ingredients that can cause allergic reactions or sensitivities. If you have certain medical history, such as difficulty urinating (urinary retention), other bladder problems (such as obstruction), stomach or intestinal obstruction (gastric retention), personal or family history of glaucoma (angle-closure type), liver disease, bowel disease (such as ulcerative colitis), slow motility of the stomach or intestines, constipation, kidney disease, prostate enlargement, specific muscle or nerve disease (myasthenia gravis) and… consult your doctor regarding the risks of using the drug.

1. Administer with caution in clinically significant bladder outlet obstruction.
2. Reports of angioedema of the face, lips, or larynx, occurring in some cases after the first dose, have been described. Also, anaphylactic reactions have been rarely reported.
3. Drowsiness was reported; Advise patients not to drive or operate heavy machinery until they know how the treatment will affect them.
4. Use with caution in patients being treated for narrow-angle glaucoma.
5. Use with caution in patients with a known history of QT prolongation or in patients taking medications that prolong the QT interval.
6. Monitor for signs of CNS antimuscarinic adverse reactions, especially after treatment initiation or dose escalation.
7. Solifenacin is a CYP3A4 substrate, co-administration of ketoconazole, a strong CYP3A4 inhibitor, significantly increased exposure to solifenacin. If co-administered with strong CYP3A4 inhibitors, modify the dose of solifenacin.

Urinacin contraindications

1. Hypersensitivity
2. Stomach retention
3. Uncontrolled narrow-angle glaucoma
4. urinary retention (pill)

Urinacin side effects (solifenacin)

Dry mouth, constipation, drowsiness, upset stomach, blurred vision, dry eyes, headache, unusual fatigue or weakness are some of the side effects of Urinacin (Solifenacin). If any of these effects persist or worsen, tell your doctor or pharmacist right away. To relieve dry mouth, eat candy or hard ice chips (sugar-free), gum (sugar-free), water, etc., or use a suitable saliva substitute. Some serious side effects of this drug include severe stomach or abdominal pain, constipation for 3 days or more, difficulty urinating, symptoms of a kidney infection (such as kidney infection symptoms), painful burning and frequent urination, fever, pink or bloody urine, changes It is mental or creative (such as confusion and illusion) and…

1. dry mouth
2. constipation
3. Blurred vision and dizziness
4. UTI
5. Indigestion
6. nausea
7. Flu
8. tiredness
9. Upper abdominal pain
10. dry eyes
11. Urinary retention
12. High blood pressure
13. depression
14. Lower limb edema
15. Vomit
16. Cough

Urinacin drug interactions

1. Category X interactions (avoid): Fusidic acid (systemic), glycopyrrolate (oral inhalation), glycopyrronium (topical), idelalisib, ipratropium (oral inhalation), levosulpiride, oxatomide, potassium chloride, potassium citrate, rufenacin, tiotropium, omeclidinium, aclidinium , simtropium, canivaptan, eloxadoline
2. Reduction of the effects of drugs by sulphenazine: acetylcholinesterase inhibitors, gastrointestinal agents (prokinetics), itopride, levosulpiride, nitroglycerin, secretin
3. Increased effects of drugs by sulphenazine: clozapine, eloxadoline, glucagon, glycopyrrolate (oral inhalation), haloperidol, opioid agonists, potassium chloride, potassium citrate, QT prolonging agents (highest risk), ramosterone, rufenacin, thiazide and thiazide-like diuretics. Tiotropium, topiramate, anticholinergic compounds, cannabinoid containing products
4. Reduction of sulphenazine effects by drugs: moderate and strong CYP3A4 inducers, dabrafenib, deferasirox, enzalutamide, erdafitinib, ivocidanib, mitotane, sarilumab, ciltuximab, tocilizumab, acetylcholinesterase inhibitors, bosentan
5. Increased effects of sulphenazine by drugs: fos-netopitant, fusidic acid (systemic), glycopyrronium (topical), idelalisib, ipratropium (oral inhalation), itraconazole, larotrectinib, erdafitinib, mianserin, mifepristone, mirabegron, netopitant, oxatomide, palbociclib, pramlintide, simprevir, Stripentol, Omclidinium

Use of Urinacin (solifenacin) during pregnancy and breastfeeding

There are no studies on the use of solifenacin in pregnant women. No adverse developmental outcomes in animal reproduction studies with oral solifenacin succinate in pregnant rats during organogenesis at a dose of 10 mg/day (1.2 times the maximum recommended human dose) [MRHD]) was not observed. Administration of doses ≥3.6 times the MRHD during organogenesis caused maternal toxicity in pregnant rats and resulted in developmental toxicity and decreased fetal body weight in the offspring. Information regarding the presence of this drug in human milk is not available, but in animal studies, this drug was found in the milk of rats. When a drug is present in animal milk, it is likely to be present in human milk.

Urinacin medicine storage conditions

Urinacin medicine should be stored at room temperature and away from light and moisture. If the expiration date has passed, dispose of the medicine according to hygienic principles. Also, keep all chemical and herbal medicines out of the reach of animals and children.

The last word of Urinacin medicine

As we said in this article from Positive Green Online Pharmacy magazine, Urinacin is introduced as an effective tool in managing urinary tract disorders and improving the quality of life of people suffering from these disorders. This drug can be effective as an important option in the treatment and control of these problems and allow people to live a better life. More research on the effectiveness and uses of this drug in the long term is recommended so that its long-term effects are more specific and its advantages and disadvantages are fully analyzed. We have described this article titled solifenacin drug from Positive Green online pharmacy magazine.

Site source: Medscape