What is Tranexamic acid?

In the field of women’s health, one of the vital and common issues that must be addressed and treated is unusual bleeding during menstruation. These bleedings can be caused by hormonal disorders, gynecological diseases or other unknown factors and have a negative impact on women’s quality of life. One of the ways to intervene and manage women’s bleeding is to use special drugs such as transacid acid or tranexamic acid. Considering the importance of reducing bleeding during women’s menstruation, this article has been prepared to review the mechanism of action, indications for use, precautions and contraindications for Tranexamic acid.

Medicinal forms of Trancid

Trancid acid drug is available in the market in the form of tablets and capsules and is known by the brand names Lysteda, Tranxamic Acid, Tranxamic Acid, Tranxamic Acid, Tranzip, etc.

Uses of Trancid (Trangesamic Acid) Tablets

Tranexamic acid is used to treat heavy bleeding during the menstrual cycle (monthly periods) in women. Tranexamic acid is in a class of drugs called antifibrinolytics. Some of the most important uses of this drug include menorrhagia, hereditary angioedema (off label), cone biopsy (off label), epistaxis (off label), hyphema (off label), hereditary angioedema (off label) and… .

Pharmacological effects and mechanism of action of Tranexamic acid drug

antifibrinolytic; Synthetic lysine amino acid derivative, which reduces hemostatic fibrin dissolution by plasmin. In the presence of tranexamic acid, plasmin lysine receptor binding sites for fibrin are occupied and prevent binding to fibrin monomers, thereby maintaining and stabilizing the fibrin structure. The maximum plasma concentration is 16.41 μg/ml (steady state) and finally it is excreted through urine mainly by glomerular filtration.

Tranexamic acid dosage

Tranexamic acid is available as a tablet for oral use. This medicine is usually taken with or without food three times a day for up to 5 days during the monthly period. You should start taking this medicine every month with the onset of menstruation. It should be noted, do not take tranexamic acid when you are not menstruating. Take this medicine at about the same time of day that you are supposed to take a dose. Take this medicine as directed by your doctor to get the most benefit from it.

Time to take Trancid tablets

Do not take tranexamic acid pills for more than 5 days in a menstrual cycle or more than 6 pills in a 24-hour period. Take the tablet of this medicine completely and avoid crushing or chewing it. Tranexamic acid is used to reduce the amount of blood lost during the menstrual cycle but does not stop menstrual bleeding. If your bleeding does not improve or worsens during treatment, call your doctor. Also, this drug is suitable for women of childbearing age, but it is not intended for use in premenstrual girls.

Dosage of tranexamic acid in adults

1. This drug is recommended for the treatment of severe cyclical menstrual bleeding in women. The recommended dose is 1300 mg orally for up to 5 days during menstruation. Also, if you have a kidney disorder, the dosage should be prescribed by your doctor.
2. For hereditary angioedema in long-term prophylaxis, 1000-1500 mg should be taken orally every 8-12 hours. If the frequency of attacks decreases, the dosage is reduced to 500 mg orally per day or every 12 hours. Also, in short-term prophylaxis, 75 mg/kg is prescribed for 5 days before and after the event in 8-12 hours.
3. Cone biopsy, 1000-1500 mg should be used every 8-12 hours.
4. Epistaxis, 1000-1500 mg every 8-12 hours for ten days.
5. Hyphema, 1000-1500 mg every 8-12 hours for 7 days.

Precautions

1. There is an increased risk of thrombosis when used simultaneously with combined oral contraceptives (unless they are contraindicated), factor IX complex concentrates, inhibitory anticoagulant concentrates or oral tretinoin.
2. Venous and arterial thrombosis or thromboembolism, as well as cases of retinal artery and retinal vein occlusion, have been reported.
3. This drug may cause cerebral edema and cerebral infarction in women with subarachnoid hemorrhage.
4. Before taking this medicine, if you are allergic to it or any of its ingredients, do not take it. Consult your doctor regarding the risks of use and drug interactions so that he can prescribe similar drugs for you if needed.
5. Tell your doctor if you are using hormonal birth control (birth control pills, patches, rings, and pills). If you are taking this medicine, your doctor will probably tell you not to take tranexamic acid. Tell your doctor and pharmacist what other prescription and over-the-counter medicines you are taking, such as vitamins, nutritional supplements, and herbal medicines.
6. If you have a history of blood clotting disease or are currently suffering from this disease; Consult your doctor regarding the risks of using Trancid so that other medications can be prescribed for you if needed.
7. If you have or have ever had kidney disease, tell your doctor before taking this medicine. Also, if the time interval between the start of your period is less than 21 days or more than 35 days, you should consult your doctor regarding the use of this medicine.

Warnings for the use of tranexamic acid

1. Tell your doctor if you are using birth control pills or other forms of birth control (such as the patch, vaginal ring, or intrauterine device). Also, if you are using contraceptives or drugs that combine hormones, stop using Trancid.
2. Tranexamic acid may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you experience shortness of breath, trouble breathing, chest tightness, facial flushing, trouble swallowing, or any swelling of your hands, face, or mouth while taking this medicine.
3. If this medicine does not reduce your bleeding after two menstrual cycles or if it seems to be losing its effect, talk to your doctor about changing the medicine or dosage.
4. Avoid taking other medications without consulting your doctor. Because Trancid has many drug interactions.

Contraindications to the use of Trancid

1. Hypersensitivity
2. Women using combined hormonal contraceptives.
3. Active thromboembolic disease (such as DVT, pulmonary embolism, or cerebral thrombosis)
4. History of thrombosis or thromboembolism, including retinal vein or artery occlusion
5. Inherent risk of thrombosis or thromboembolism (eg, thrombogenic valvular disease, thrombogenic heart rhythm disease, or hypercoagulability)

Tranexamic acid side effects

Headache or lightheadedness, anemia, migraine, back pain, abdominal pain, musculoskeletal pain, cramps and muscle spasms are some of the side effects of Tranexamic acid. Also, according to some post-marketing reports, this medicine has caused nausea, vomiting and diarrhea and some allergic skin reactions. Cases have been associated with the simultaneous use of combined hormonal contraceptives. Thromboembolic events (such as DVT, pulmonary embolism, cerebral thrombosis, acute renal cortical necrosis, central retinal artery and vein occlusion) have also been reported as other side effects of this drug.

1. Headache
2. Nasal and sinus symptoms
3. back ache
4. stomach ache
5. Musculoskeletal pain
6. Arthralgia
7. Cramps and muscle spasms
8. Migraine
9. Anemia
10. tiredness

Trancid drug interactions

Patients, before going to the doctor, prepare a list of chemical and herbal medicines you use and show them to him. Your doctor should prescribe medicine according to the drugs used, the patient’s age, physical condition, etc., in order to avoid side effects and drug interactions in addition to the benefits. Drug interactions may change how your medications work or increase your risk of serious side effects. Never stop, reduce or increase your dose without consulting your doctor.

1. Class X interactions (avoid): Anticoagulant complex (human), estrogen derivatives (found in birth control products), progestins (found in birth control products)
2. Enhancement of drug effects by tranexamic acid: an anticoagulant complex (human)
3. Increasing the effects of tranexamic acid by drugs: estrogen derivatives (contraception), progestins (contraception), tretinoin (systemic).

Taking Tranexamic acid during pregnancy and breastfeeding

It is not recommended to use this medicine during pregnancy. There are no specific information regarding Trancid in pregnant women to assess the risk associated with birth defects, miscarriage, or adverse maternal or fetal outcomes. Tranexamic acid crosses the placenta. Animal reproduction studies have not identified adverse developmental outcomes following oral administration of this drug to pregnant rats at doses up to 4 times the recommended human dose.

The effect of Trancid tablets on breastfeeding

Transacid drug is present in breast milk with a concentration of about one hundredth of the corresponding serum concentration. The amount of tranexamic acid absorbed by the infant is unknown. There are no adequate data on the effects of this drug on nursing infants or breast milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for treatment and any potential adverse effects on the breastfed child from the mother’s treatment or underlying disease.

Tranexamic acid storage conditions

Trancid acid medicine should be stored at room temperature and away from light. It is also important to keep all medications out of the reach of children, as many forms of medication (such as weekly tablets and eye drops, creams, patches, and inhalers) are not child-resistant and can be easily opened by young children. . Unnecessary medications should be disposed of in specific ways to ensure that pets, children, and other people cannot ingest them.

The last word about Trancid medicine

As we said in this article from Darokhaneh Sabz online magazine, transacid acid can be of great importance as an option in the management of women’s bleeding. Considering the need for more research and more experience in this field, we hope that this article will help doctors, researchers and women suffering from gynecological bleeding to find more appropriate treatment and improvement strategies to manage these problems and from the negative effects of bleeding on the quality of life. prevent life

Site source: Medscape